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A perspective on the changing landscape of HTS.
Lanne A, Usselmann LEJ, Llowarch P, Michaelides IN, Fillmore M, Holdgate GA. Lanne A, et al. Among authors: michaelides in. Drug Discov Today. 2023 Aug;28(8):103670. doi: 10.1016/j.drudis.2023.103670. Epub 2023 Jun 14. Drug Discov Today. 2023. PMID: 37328053 Review.
Total Synthesis of (-)-Himalensine A.
Shi H, Michaelides IN, Darses B, Jakubec P, Nguyen QNN, Paton RS, Dixon DJ. Shi H, et al. Among authors: michaelides in. J Am Chem Soc. 2017 Dec 13;139(49):17755-17758. doi: 10.1021/jacs.7b10956. Epub 2017 Nov 27. J Am Chem Soc. 2017. PMID: 29120635
Put a ring on it: application of small aliphatic rings in medicinal chemistry.
Bauer MR, Di Fruscia P, Lucas SCC, Michaelides IN, Nelson JE, Storer RI, Whitehurst BC. Bauer MR, et al. Among authors: michaelides in. RSC Med Chem. 2021 Jan 7;12(4):448-471. doi: 10.1039/d0md00370k. eCollection 2021 Apr 28. RSC Med Chem. 2021. PMID: 33937776 Free PMC article. Review.
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Collie GW, Michaelides IN, Embrey K, Stubbs CJ, Börjesson U, Dale IL, Snijder A, Barlind L, Song K, Khurana P, Phillips C, Storer RI. Collie GW, et al. Among authors: michaelides in. ACS Med Chem Lett. 2020 Dec 8;12(1):162-167. doi: 10.1021/acsmedchemlett.0c00392. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488978 Free PMC article.
Discovery of a selective c-MET inhibitor with a novel binding mode.
Collie GW, Barlind L, Bazzaz S, Börjesson U, Dale IL, Disch JS, Habeshian S, Jetson R, Khurana P, Madin A, Michaelides IN, Peng L, Snijder A, Stubbs CJ. Collie GW, et al. Among authors: michaelides in. Bioorg Med Chem Lett. 2022 Nov 1;75:128948. doi: 10.1016/j.bmcl.2022.128948. Epub 2022 Aug 17. Bioorg Med Chem Lett. 2022. PMID: 35987508 Free article.
Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
Michaelides IN, Collie GW, Börjesson U, Vasalou C, Alkhatib O, Barlind L, Cheung T, Dale IL, Embrey KJ, Hennessy EJ, Khurana P, Koh CM, Lamb ML, Liu J, Moss TA, O'Neill DJ, Phillips C, Shaw J, Snijder A, Storer RI, Stubbs CJ, Han F, Li C, Qiao J, Sun DQ, Wang J, Wang P, Yang W. Michaelides IN, et al. J Med Chem. 2023 Jul 13;66(13):8782-8807. doi: 10.1021/acs.jmedchem.3c00401. Epub 2023 Jun 21. J Med Chem. 2023. PMID: 37343272 Free PMC article.
15 results